Woutersz T B
J Reprod Med. 1981 Dec;26(12):615-20.
A multicenter study was conducted to evaluate the efficacy and acceptability of a combination oral contraceptive containing norgestrel, 0.3 mg, and ethinyl estradiol, 0.03 mg. A total of 1,700 women were treated for 22,489 cycles. Only two pregnancies occurred (Pearl index, 0.20 per 100 woman-years). Cycle control was excellent, and the incidence of breakthrough bleeding, spotting and amenorrhea was low as compared to other reported series of similar low-dose combination contraceptives. No serious side effects were reported, and the drug had no demonstrable adverse effects on weight and blood pressure. The use of this low-dose oral contraceptive appears to provide effective birth control with a high laboratory index of safety and low incidence of side effects.
开展了一项多中心研究，以评估一种含有0.3毫克炔诺孕酮和0.03毫克炔雌醇的复方口服避孕药的疗效和可接受性。共有1700名女性接受了22489个周期的治疗。仅发生了两例妊娠（Pearl指数为每100妇女年0.20）。周期控制良好，与其他报道的类似低剂量复方避孕药系列相比，突破性出血、点滴出血和闭经的发生率较低。未报告严重副作用，该药物对体重和血压无明显不良影响。使用这种低剂量口服避孕药似乎能提供有效的避孕效果，且安全性实验室指标高，副作用发生率低。
