Gaffney E F, Panner B J
Nephron. 1981;29(5-6):209-15. doi: 10.1159/000182371.
Quantitative and semi-quantitative morphological analysis of 41 cases of idiopathic membranous glomerulonephritis revealed glomerular hypercellularity in 24 cases and abnormal parietal epithelium in 25 cases. Abnormal parietal epithelium included crescents and prominent parietal epithelium (at least ten enlarged cells with round or ovoid nuclei lining Bowman's capsule of two or more glomeruli per biopsy). The clinical course (mean follow-up = 5.1 years) was correlated with biopsy findings. 8 to 17 patients with normocellular glomeruli, but only 3 of 24 patients with hypercellular glomeruli achieved complete clinical remission. 10 of 16 patients with normal parietal epithelium, but only 1 of 25 patients with abnormal parietal epithelium achieved complete remission. Of 9 urine patients, all but 1 had abnormal parietal epithelium in their biopsies. Glomerular cellularity and parietal epithelium may be useful prognostic indices in idiopathic membranous glomerulonephritis.
对41例特发性膜性肾小球肾炎进行的定量和半定量形态学分析显示，24例存在肾小球细胞增多，25例存在壁层上皮异常。壁层上皮异常包括新月体和显著的壁层上皮（每次活检中至少有十个细胞核呈圆形或椭圆形的增大细胞排列在两个或更多肾小球的鲍曼囊周围）。临床病程（平均随访时间 = 5.1年）与活检结果相关。8至17例肾小球细胞数正常的患者实现了完全临床缓解，但24例肾小球细胞增多的患者中只有3例达到这一效果。16例壁层上皮正常的患者中有10例实现了完全缓解，但25例壁层上皮异常的患者中只有1例达到这一效果。在9例尿检异常的患者中，除1例之外，其余患者的活检均显示壁层上皮异常。肾小球细胞数和壁层上皮可能是特发性膜性肾小球肾炎有用的预后指标。
