Zadina J E, Kastin A J, Fabre L A, Coy D H
Pharmacol Biochem Behav. 1981 Dec;15(6):961-4. doi: 10.1016/0091-3057(81)90062-9.
An LHRH analog known to inhibit ovulation in the rat ([N-Ac-Phe1, D-p-Cl-Phe2, D-Trp3,6]-LHRH) was tested for its effects on sexual receptivity. The dose of 500 ng/rat was found in dose-response experiments to be most active and was further investigated for its behavioral effects in rats treated with either estrogen or estrogen plus progesterone. The analog significantly facilitated the behavior of rats in regimens producing low [estradiol benzoate (EB) (2 microgram)] and intermediate [EB (2 microgram) plus progesterone (2.5 mg)] levels of sexual behavior. In rats given regimens producing high behavioral scores [EB (5 microgram) plus progesterone (1 mg)], the peptide did not reduce mating behavior. In the same experiment, rats given EB (5 microgram) but not progesterone showed significantly higher scores after the LHRH analog only if they had been designated "responders" by a previous screening test with 1 microgram LHRH. These results demonstrate that in animals showing low, intermediate, or high levels of sexual behavior, the LHRH analog can affect mating behavior in a direction quite different from that exerted on pituitary reproductive functions.
一种已知能抑制大鼠排卵的促性腺激素释放激素（LHRH）类似物（[N-乙酰苯丙氨酸1，对氯苯丙氨酸2，色氨酸3,6]-LHRH）被测试其对性接受能力的影响。在剂量反应实验中发现，500纳克/大鼠的剂量最为有效，并进一步研究了其对用雌激素或雌激素加孕酮处理的大鼠的行为影响。该类似物在产生低[苯甲酸雌二醇（EB）（2微克）]和中等[EB（2微克）加孕酮（2.5毫克）]性行为水平的方案中显著促进了大鼠的行为。在给予产生高行为评分[EB（5微克）加孕酮（1毫克）]方案的大鼠中，该肽并未降低交配行为。在同一实验中，仅给予EB（5微克）而未给予孕酮的大鼠，只有在先前用1微克LHRH进行筛选测试被指定为“反应者”时，在给予LHRH类似物后才显示出显著更高的评分。这些结果表明，在表现出低、中或高水平性行为的动物中，LHRH类似物对交配行为的影响方向与对垂体生殖功能的影响方向截然不同。
