Løvgren N A, Poulsen J, Schwartz T W
Scand J Gastroenterol. 1981;16(6):811-6. doi: 10.3109/00365528109181008.
The secretion of pancreatic polypeptide (PP) was studied in 38 duodenal ulcer patients before, 4 months after, and, in 25 patients, again 18 months after either selective gastric vagotomy or parietal cell vagotomy. Selective gastric vagotomy on average reduced the PP response to food measured 4 months after operation to 20% of the preoperative value. The prolonged PP response (30-120 min) increased to 50% from the 4th to the 18th postoperative month (p less than 0.005). Parietal cell vagotomy did not significantly change the PP response to food, although in a few patients (3/15) the response was reduced to below one third of the preoperative value. The PP response to insulin hypoglycemia was measured after operation in 16 patients; those who had a reduced PP response to food demonstrated a response to hypoglycemia which was reduced to the same extent. It is concluded that PP secretion is generally unaffected by parietal cell vagotomy but is impaired after selective gastric vagotomy and that the prolonged PP response to food is partially regenerated after vagotomy. It is suggested that selective gastric vagotomy interferes with the vagal innervation of the PP-rich head of the pancreas.
对38例十二指肠溃疡患者在术前、术后4个月以及25例患者在选择性胃迷走神经切断术或壁细胞迷走神经切断术后18个月再次研究了胰多肽（PP）的分泌情况。选择性胃迷走神经切断术平均将术后4个月测得的PP对食物的反应降低至术前值的20%。延长的PP反应（30 - 120分钟）从术后第4个月到第18个月增加到50%（p < 0.005）。壁细胞迷走神经切断术并未显著改变PP对食物的反应，尽管少数患者（3/15）的反应降低至术前值的三分之一以下。术后对16例患者测量了PP对胰岛素低血糖的反应；那些对食物的PP反应降低的患者对低血糖的反应也降低到相同程度。得出的结论是，PP分泌通常不受壁细胞迷走神经切断术的影响，但在选择性胃迷走神经切断术后受损，并且迷走神经切断术后对食物延长的PP反应会部分再生。有人提出，选择性胃迷走神经切断术会干扰富含PP的胰头的迷走神经支配。
