Gambardella S, Felici M G, Annibale B, Delle Fave G F, Jacoangeli F, Spallone V, Menzinger G
J Endocrinol Invest. 1986 Feb;9(1):1-4. doi: 10.1007/BF03348051.
A protein-rich meal and insulin-induced hypoglycemia (ITT) are two of the most important stimuli on pancreatic polypeptide (PP) secretion in diabetic patients. Previous studies have shown a reduced PP response to ITT in diabetic patients with autonomic neuropathy (AN). Twelve patients without AN (mean age 44 +/- 10.8 yr, mean duration of diabetes 11 +/- 5.6 yr), 9 with AN (51.4 +/- 6 yr, 15.8 +/- 6.9 yr) and 9 controls (N) were studied. AN was assessed by the evaluation of the beat-to-beat variation of the heart rate during deep breathing. PP secretion was stimulated by a protein-rich meal (200 g meat, 150 g milk). All insulin-dependent diabetic (IDD) patients lacked circulating PP antibodies. All diabetic patients showed a significant reduction in the early vagal phase compared to controls. This behavior was more evident in diabetic patients with AN and the secondary phase of these two groups overlapped with the response of controls. These data may be explained by the initial alterations of vagal functions not detectable by current methods.
富含蛋白质的膳食和胰岛素诱导的低血糖症（ITT）是糖尿病患者胰腺多肽（PP）分泌的两种最重要刺激因素。先前的研究表明，患有自主神经病变（AN）的糖尿病患者对ITT的PP反应降低。对12例无AN的患者（平均年龄44±10.8岁，平均糖尿病病程11±5.6年）、9例有AN的患者（51.4±6岁，15.8±6.9年）和9例对照（N）进行了研究。通过评估深呼吸时心率的逐搏变化来评估AN。通过富含蛋白质的膳食（200克肉、150克牛奶）刺激PP分泌。所有胰岛素依赖型糖尿病（IDD）患者均缺乏循环PP抗体。与对照组相比，所有糖尿病患者的早期迷走神经期均显著缩短。这种表现在患有AN的糖尿病患者中更为明显，且这两组的第二期与对照组的反应重叠。这些数据可能是由目前方法无法检测到的迷走神经功能的初始改变所解释的。
