一种酵母对咪唑类抗真菌药物的异常反应。
Unusual response of a yeast to imidazole antifungals.
作者信息
Ball E H, Forbes E C, Gentles J C
出版信息
Sabouraudia. 1981 Dec;19(4):287-94. doi: 10.1080/00362178185380461.
Thiamin was shown to relieve preferentially the toxicity of econazole for a yeast which showed an unusual response to imidazole drugs. The possible role of this vitamin in the response of the yeast to imidazoles is discussed. An investigation of the effect of a second exposure of yeasts to imidazole drugs showed that there is an increase in sensitivity when the cells are transferred directly to fresh medium containing the same concentrations of the drug, and a decrease in sensitivity following transfer via drug-free medium.
硫胺素被证明能优先缓解益康唑对一种对咪唑类药物有异常反应的酵母的毒性。本文讨论了这种维生素在酵母对咪唑类药物反应中的可能作用。对酵母再次暴露于咪唑类药物的影响进行的研究表明，当细胞直接转移到含有相同浓度药物的新鲜培养基中时，敏感性会增加，而通过无药物培养基转移后敏感性会降低。
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