Naparstek Y, Weiler-Ravell D, Shemer J, Englehard D, Sack J, Spira D T, Adler J
Am J Trop Med Hyg. 1981 Nov;30(6):1342-3. doi: 10.4269/ajtmh.1981.30.1342.
Fifty-two patients with severe chloroquine resistant Plasmodium falciparum malaria were treated in a randomized double blind study with either quinine and a single dose of pyrimethamine-sulfadoxine (Fansidar) or quinine alone. Although no statistically significant differences were observed, the 25 patients who received both drugs responded faster and had a more favorable outcome (no deaths) when compared to the 27 who received quinine alone (2 deaths).
在一项随机双盲研究中，对52例患有严重氯喹抗性恶性疟原虫疟疾的患者进行了治疗，一组给予奎宁加单剂量乙胺嘧啶 - 磺胺多辛（Fansidar），另一组仅给予奎宁。虽然未观察到统计学上的显著差异，但与仅接受奎宁治疗的27例患者（2例死亡）相比，接受两种药物治疗的25例患者反应更快，预后更良好（无死亡）。
