对用人鼠细胞杂交体引发的抗HLA - A2、HLA - A3和HLA - B27异种抗血清的免疫化学分析。
Immunochemical analysis of anti-HLA-A2, HLA-A3, and HLA-B27 xenoantisera elicited with hybrids between human and murine cells.
作者信息
Pellegrino M A, Ng A K, Russo C, Glassy M, Ferrone S
出版信息
Immunogenetics. 1981;14(1-2):141-52. doi: 10.1007/BF00344307.
Rabbits were immunized with hybrids constructed with human and murine cells. Serological and immunochemical studies showed that xenoantiserum 1595 is operationally specific for HLA-A2, xenoantisera 0806 and 0746 for HLA-A3 and xenoantiserum 0745 for HLA-B27. The Fab2 blocking assay suggests a spatial relationship between allotypic determinants recognized by the xenoantisera and those reacting with the HLA-A, B-specific monoclonal antibodies (MoAb) Q1/28, 6/31, Q6/64, and CR-1 and the anti-beta 2-microglobulin (beta 2-mu) MoAb NAMB-1.
用人类和鼠类细胞构建的杂种对兔子进行免疫。血清学和免疫化学研究表明，异种抗血清1595对HLA - A2具有操作特异性，异种抗血清0806和0746对HLA - A3具有操作特异性，而异种抗血清0745对HLA - B27具有操作特异性。Fab2阻断试验表明，异种抗血清识别的同种异型决定簇与与HLA - A、B特异性单克隆抗体（MoAb）Q1/28、6/31、Q6/64和CR - 1以及抗β2 - 微球蛋白（β2 - mu）MoAb NAMB - 1反应的同种异型决定簇之间存在空间关系。
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