Christensen K K, Christensen P, Lindberg A, Lindén V
Int Arch Allergy Appl Immunol. 1982;67(1):7-12. doi: 10.1159/000232980.
Serum antibodies against various carbohydrate antigens were studied in 16 mothers of infants with serious infections caused by group B streptococci (GBS) (the study group), and compared with a control group of 29 urogenital carriers of GBS who gave birth to neonatally healthy infants. Using a radioimmunoassay for the determination of antibodies to GBS types Ia, Ib, II and III, it was found that the study group had significantly lower levels of IgG antibodies to each of the 4 GBS types than the control group. The IgG levels against Salmonella BO and DO, Yersinia enterocolitica 03, Francisella tularense and Streptococcus pneumonia types 3, 6, 9, 19 and 23 purified carbohydrate antigens were determined using an ELISA technique. Significantly more individuals in the study group than in the control group had low levels of IgG antibodies against 8 of 9 carbohydrate antigens. No difference was found in IgM levels against 3 of 4 antigens studied, while the study group showed significantly more IgM antibodies against Salmonella DO than the controls. These results indicate that mothers of GBS-infected infants might be poor IgG antibody responders to bacterial carbohydrate antigens in general.
对16名患有B族链球菌（GBS）引起的严重感染婴儿的母亲（研究组），研究了其针对各种碳水化合物抗原的血清抗体，并与29名GBS泌尿生殖道携带者且所生新生儿健康的对照组进行比较。采用放射免疫测定法测定针对GBS Ia、Ib、II和III型的抗体，发现研究组针对4种GBS类型中每种类型的IgG抗体水平均显著低于对照组。使用酶联免疫吸附测定（ELISA）技术测定针对沙门氏菌BO和DO、小肠结肠炎耶尔森菌03、土拉热弗朗西斯菌以及肺炎链球菌3、6、9、19和23型纯化碳水化合物抗原的IgG水平。研究组中IgG抗体水平低的个体在9种碳水化合物抗原中的8种上显著多于对照组。在所研究的4种抗原中的3种上，两组的IgM水平未发现差异，但研究组针对沙门氏菌DO的IgM抗体显著多于对照组。这些结果表明，一般而言，GBS感染婴儿的母亲可能对细菌碳水化合物抗原的IgG抗体反应较差。
