McIlwraith C W
J Am Vet Med Assoc. 1982 Feb 1;180(3):239-50.
Current concepts of pathogenesis, diagnosis, and treatment of equine degenerative joint disease are presented on the basis of recently acquired experimental and clinical knowledge. A number of concepts of pathogenesis need modification and the rationale of some of the newer treatments requires definition. Synovitis and other soft tissue changes are important components of the pathogenesis in addition to direct trauma to the articular cartilage. Loss of glycosaminoglycans constitutes an important biochemical "lesion" in the articular cartilage, making it weak and susceptible to trauma. Recognition of these early changes and appropriate treatment of them are important. Treatment methods include physical therapy, use of anti-inflammatory drugs, joint lavage, sodium hyaluronate, and synovectomy. When there are cartilage and bony changes, the use of articular cartilage curettage, osteophyte removal, radiation therapy, and surgical arthrodesis remain appropriate in some cases. Studies continue to develop agents capable of promoting the synthesis of the important biochemical components of the articular cartilage and its subsequent healing.
基于最近获得的实验和临床知识，介绍了马退行性关节病的发病机制、诊断和治疗的当前概念。一些发病机制的概念需要修正，一些新治疗方法的原理需要明确。除了关节软骨直接损伤外，滑膜炎和其他软组织变化是发病机制的重要组成部分。糖胺聚糖的丢失是关节软骨中一个重要的生化“病变”，使其变得脆弱且易受损伤。认识到这些早期变化并对其进行适当治疗很重要。治疗方法包括物理治疗、使用抗炎药物、关节灌洗、透明质酸钠和滑膜切除术。当出现软骨和骨质变化时，在某些情况下，使用关节软骨刮除术、骨赘切除术、放射治疗和手术关节固定术仍然是合适的。研究继续开发能够促进关节软骨重要生化成分合成及其后续愈合的药物。
