T细胞替代因子替代I-J +独特型特异性T辅助细胞。
T cell replacing factor substitutes for an I-J+ idiotype-specific T helper cell.
作者信息
Jayaraman S, Swierkosz J E, Bellone C J
出版信息
J Exp Med. 1982 Feb 1;155(2):641-6. doi: 10.1084/jem.155.2.641.
Abstract
An in vitro system for the study of idiotype (Id) expression on antitrimethylamino hapten antibody-producing cells and its regulation by two classes of helper T cells is described. These cells are distinguished in four ways: one requires a hapten-carrier bridge and gives a good response that is low in Id; it does not bind to Id-coated dishes and is not affected by anti-I-J plus complement. The other requires antigen but not a hapten-carrier bridge, is bound by Id-coated dishes and is killed by anti-I-J and complement. The Id-specific cell appears to be antigen specific and acts via a soluble factor(s).
摘要
本文描述了一种体外系统，用于研究抗三甲基氨基半抗原抗体产生细胞上独特型（Id）的表达及其受两类辅助性T细胞的调节。这些细胞可通过四种方式区分：一种需要半抗原-载体桥接，能产生良好反应，Id水平较低；它不与Id包被的培养皿结合，不受抗I-J加补体的影响。另一种需要抗原但不需要半抗原-载体桥接，能与Id包被的培养皿结合，并被抗I-J和补体杀死。Id特异性细胞似乎是抗原特异性的，并通过一种或多种可溶性因子起作用。
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本文引用的文献
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J Exp Med. 1980 Oct 1;152(4):893-904. doi: 10.1084/jem.152.4.893.
2
Cell cooperation during in vivo anti-hapten antibody responses. V. Two synergistic Ly-1+23- helper T cells with distinctive specificities.体内抗半抗原抗体应答过程中的细胞协作。V. 两种具有独特特异性的协同性Ly-1⁺23⁻辅助性T细胞。
Eur J Immunol. 1980 Apr;10(4):231-6. doi: 10.1002/eji.1830100402.
3
4
5
Anti-phenyltrimethylamino immunity in mice. II. L-Tyrosine-p-azophenyltrimethylammonium-induced suppressor T cells selectively inhibit the expression of B-cell clones bearing a cross-reactive idiotype.小鼠中的抗苯基三甲基氨基免疫。II. L-酪氨酸对偶氮苯基三甲基铵诱导的抑制性T细胞选择性抑制带有交叉反应性独特型的B细胞克隆的表达。
J Exp Med. 1980 Mar 1;151(3):528-41. doi: 10.1084/jem.151.3.528.
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Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody.在用抗μ抗体处理的小鼠中，表达T15独特型所需的抗原特异性辅助性T细胞缺失。
Eur J Immunol. 1980 Feb;10(2):159-63. doi: 10.1002/eji.1830100217.
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