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胎儿酒精综合征:母亲酗酒的一个难题。

Fetal alcohol syndrome: a dilemma of maternal alcoholism.

作者信息

Krous H F

出版信息

Pathol Annu. 1981;16 Pt 1:295-311.

PMID:7036069
Abstract

The existence of FAS can no longer be denied; reports of greater than 200 cases which fall into a phenotypically recognizable continuum justify its existence. At this point, however, it is probably prudent to withhold judgment of the specific human teratogenicity of alcohol until more refined information regarding dose-risk relationships are available not only from humans, but also from animal models, including primates. It may be that Fetal Alcohol Syndrome, at this point, should be considered the Fetal Alcoholism Syndrome. At any rate, until much more is known, it would seem advisable to observe the Biblical admonition the "thou shalt conceive, and bear a son; and (therefore now drink no wine or strong drink" (Judges 13:7).

摘要

胎儿酒精综合征(FAS)的存在已无法否认;超过200例符合表型可识别连续谱的病例报告证明了其存在。然而,在这一点上,在获得不仅来自人类,也来自包括灵长类动物在内的动物模型的关于剂量-风险关系的更精确信息之前,对酒精特定的人类致畸性暂不做判断可能较为谨慎。此时,胎儿酒精综合征或许应被视为胎儿酒精中毒综合征。无论如何,在了解更多情况之前,遵循《圣经》的告诫“你必怀孕,生一个儿子,所以清酒浓酒都不可喝”(《士师记》13:7)似乎是明智的。

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