谷胱甘肽转移酶和微粒体混合功能氧化酶对1,2 - 二溴乙烷的代谢活化作用：形成两种反应性代谢物的进一步证据。
Metabolic activation of 1,2-dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites.
作者信息
Shih T W, Hill D L
出版信息
Res Commun Chem Pathol Pharmacol. 1981 Sep;33(3):449-61.
PMID:7036301
Abstract
In liver cytosolic preparations containing added glutathione, radioactivity from [14C]1,2-dibromoethane becomes bound preferentially to added polycytidylic acid. When microsomes and NADPH are present, however, the radioactivity becomes bound selectively to microsomal proteins.
摘要
在含有添加型谷胱甘肽的肝脏胞质制剂中，[14C]1,2 - 二溴乙烷的放射性优先与添加的聚胞苷酸结合。然而，当存在微粒体和NADPH时，放射性则选择性地与微粒体蛋白结合。
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