Toluzakova N V
Zh Mikrobiol Epidemiol Immunobiol. 1981 Oct(10):68-71.
The possibility of reproducing specific postinfectious antishigella immunity on the pulmonary model (by the intranasal infection of white mice) is shown. This method revealed that 2 compared Sh. sonnei strains, typical representatives of enzymatic types II and III with colicinogenic labels S5 and IE2 respectively, had unequal immunogenicity. Strain II S5 belonging to the most virulent type of Sh. sonnei possessed noticeably greater immunogenicity. Strain III IE2 with lesser immunogenicity was the representative of a less virulent variety of these bacteria. The results thus obtained were in complete accord with the data contained in the literature on the direct relation between the degree of virulence possessed by Sh. sonnei and their immunogenicity, as well as on the significance of the immunological factor in the epidemiology of Sh. sonnei dysentery.
研究显示了在肺部模型上（通过鼻内感染小白鼠）再现特定感染后抗志贺氏菌免疫力的可能性。该方法表明，两种分别带有产大肠杆菌素标签S5和IE2的宋内志贺氏菌菌株，即酶型II和III的典型代表，其免疫原性不相等。属于宋内志贺氏菌最具毒力类型的菌株II S5具有明显更强的免疫原性。免疫原性较低的菌株III IE2是这些细菌中毒力较弱变种的代表。由此获得的结果与文献中关于宋内志贺氏菌的毒力程度与其免疫原性之间的直接关系以及免疫因素在宋内志贺氏菌痢疾流行病学中的意义的数据完全一致。
