Paltyshev I P
Zh Mikrobiol Epidemiol Immunobiol. 1975 Dec(12):38-43.
An attempt was made of using for the purpose of studying the virulence of Sh. sonnei of the method of determination of autoimmune plaque-forming cells in infected albino mice. By the mentioned method a total of 231 strains of Sh. sonnei of various biochemical types were examined. The virulence of 103 strains was checked in paralled by the keratoconjunctival test. It was shown that the method of determination of the autoimmune plaque-forming cells in the blood of infected mice could be used as a test for the virulence of Sh. sonnei, which was more sensitive than the keratoconjunctival test. Among the cultures studied 14.7% proved to be avirulent, 51.5%-of low virulence, 21.2%-moderately virulent, and 12.6%-highly virulent. Strains of the II biotype proved to be the most virulent, and strains of the III biotype-the least. The virulence of the cultures isolated from the patients with acute dysentery was more than double that of the cultures isolated from persons who came in contact with the patients.
有人尝试用测定感染白化小鼠自身免疫性噬斑形成细胞的方法来研究宋内志贺菌的毒力。用上述方法共检测了231株不同生化类型的宋内志贺菌。同时用角膜结膜试验对103株菌的毒力进行了平行检测。结果表明，测定感染小鼠血液中自身免疫性噬斑形成细胞的方法可作为检测宋内志贺菌毒力的试验，该方法比角膜结膜试验更敏感。在所研究的培养物中，14.7%被证明无毒力，51.5%毒力低，21.2%毒力中等，12.6%毒力高。II生物型菌株毒力最强，III生物型菌株毒力最弱。从急性痢疾患者分离出的培养物的毒力比从与患者接触者分离出的培养物的毒力高出一倍多。
