Mörlin C, Aberg H
Acta Chir Scand. 1981;147(3):169-72.
The effect of five days' regimen with a low-sodium diet (approximately 20 mmol Na+ per day) and with 40 mg of furosemide (Lasix) daily on the blood pressure, the renin-aldosterone system and the electrolyte balance was studied in 42 hypertensive patients who received no antihypertensive drugs for four weeks prior to the investigation. Twenty-three of the patients had renal artery stenosis. Both patients with and those without such stenosis showed a significant decrease in systolic and diastolic blood pressure and in the serum concentrations of sodium and potassium and urinary excretion of sodium. A concomitant increase in plasma renin activity in peripheral veins and in urinary excretion of aldosterone was found both in patients without and in those with renal artery stenosis, but in the latter group this response seemed to be less pronounced.
在42例高血压患者中进行了研究，这些患者在调查前四周未服用抗高血压药物，研究了为期五天的低钠饮食（每天约20 mmol钠）和每天40 mg速尿（速尿）方案对血压、肾素-醛固酮系统和电解质平衡的影响。其中23例患者有肾动脉狭窄。有和没有这种狭窄的患者收缩压和舒张压、血清钠和钾浓度以及尿钠排泄均显著降低。在没有肾动脉狭窄和有肾动脉狭窄的患者中，均发现外周静脉血浆肾素活性和醛固酮尿排泄同时增加，但在后一组中，这种反应似乎不太明显。
