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正常和高脂血症大鼠灌注肝脏中甘油磷酸乙酰转移酶活性：胰高血糖素的作用

Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect.

作者信息

Tessari P, Meneghel A, Avogaro A, Duner E, Del Prato S, Tuzzato M, Tiengo A

出版信息

Acta Diabetol Lat. 1981 Oct-Dec;18(4):357-63. doi: 10.1007/BF02042820.

DOI:10.1007/BF02042820
PMID:7036619
Abstract

Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.

摘要

在饮食诱导的高脂血症大鼠的离体灌注肝脏中测定了线粒体甘油磷酸乙酰转移酶活性（GPAT），发现其与正常大鼠相比显著增加。肝脏甘油三酯输出与GPAT之间存在正相关。灌注10^(-5) M胰高血糖素可使GPAT水平显著降低。提示胰高血糖素的降脂作用也可能通过抑制GPAT活性来介导。

相似文献

1
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2
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本文引用的文献

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THE COLORIMETRIC MICRO-DETERMINATION OF NON-ESTERIFIED FATTY ACIDS IN PLASMA.血浆中非酯化脂肪酸的比色微量测定
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Utilization of exogenous free fatty acids for the production of very low density lipoprotein triglyceride by livers of carbohydrate-fed rats.用碳水化合物喂养的大鼠肝脏利用外源性游离脂肪酸生产极低密度脂蛋白甘油三酯。
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An enzymatic explanation for dietary induced alterations in hepatic glycerolipid metabolism.饮食诱导的肝脏甘油脂质代谢改变的酶学解释。
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10
A role for the microtubular system in the release of very low density lipoproteins by perfused mouse livers.微管系统在灌注小鼠肝脏释放极低密度脂蛋白中的作用。
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