Bleehen S S, Slater D N, Mahood J, Church R E
Br J Dermatol. 1982 Jan;106(1):9-18. doi: 10.1111/j.1365-2133.1982.tb00896.x.
Five patients with reticular erythematous mucinosis were studied by skin biopsy and phototesting. Light microscopy showed a dermal mononuclear cell infiltrate (composed largely of lymphocytes), separation of collagen bundles and fragmentation of elastic fibres. Histochemical stains showed increased dermal mucin with a profile consistent with hyaluronic acid. In one case, the ultrastructural distribution of mucin was demonstrated using colloidal iron staining, electron microscopy and X-ray microanalysis. In two cases, virus-like tubular aggregates were identified in the cytoplasm of dermal endothelial cells and pericytes. Immunofluorescent staining for immunoglobulins, fibrin and complement was negative.
对5例网状红斑性黏蛋白病患者进行了皮肤活检和光试验。光镜检查显示真皮单核细胞浸润（主要由淋巴细胞组成）、胶原束分离和弹性纤维断裂。组织化学染色显示真皮黏蛋白增加，其特征与透明质酸一致。在1例病例中，使用胶体铁染色、电子显微镜和X射线微分析证实了黏蛋白的超微结构分布。在2例病例中，在真皮内皮细胞和周细胞的细胞质中发现了病毒样管状聚集体。免疫球蛋白、纤维蛋白和补体的免疫荧光染色均为阴性。
