Prasad A S, Lei K Y, Moghissi K S, Stryker J C, Oberleas D
Am J Obstet Gynecol. 1976 Aug 15;125(8):1063-9. doi: 10.1016/0002-9378(76)90809-7.
The interactions of oral contraceptive agents (OCA's) with vitamins were studied in a large population of women. In the upper socioeconomic groups, higher incidences of abnormal clinical signs related to vitamin deficiencies were seen in OCA users than in the control subjects. Plasma pyridoxal phosphate and red cell and serum folate were lower in subjects using OCA's in the upper socioeconomic group as compared to levels in the control subjects. Reduction in erythrocyte glutamic oxalacetic transaminase (EGOT) activity and elevation in the EGOT-stimulation test were observed in subjects using OCA's in both upper and lower socioeconomic groups. These observations suggest a relatively deficient state with respect to vitamins B6 and folic acid in OCA users. No significant effect on serum vitamin B12 was observed as a result of OCA administration.
在大量女性群体中研究了口服避孕药（OCA）与维生素之间的相互作用。在上层社会经济群体中，口服避孕药使用者出现与维生素缺乏相关的异常临床体征的发生率高于对照组。与对照组相比，上层社会经济群体中使用口服避孕药的受试者血浆磷酸吡哆醛、红细胞和血清叶酸水平较低。在上层和下层社会经济群体中使用口服避孕药的受试者均观察到红细胞谷草转氨酶（EGOT）活性降低以及EGOT刺激试验升高。这些观察结果表明口服避孕药使用者在维生素B6和叶酸方面处于相对缺乏状态。口服避孕药给药后未观察到对血清维生素B12有显著影响。
