Kind P R
Clin Chim Acta. 1982 Feb 26;119(1-2):89-97. doi: 10.1016/0009-8981(82)90408-9.
The isoenzyme forms of N-acetyl-beta-D-glucosaminidase (NAG) have been studied in the urine of patients with renal disease, those with stable and rejecting renal transplants, and after surgery. Besides the increase in total urinary NAG excretion as an indicator of renal damage, changes were shown in the percentage of the intermediate isoenzyme forms of the enzyme, the greatest increase being demonstrated in the urine of patients following major surgery. Similar changes were found in some patients with rejecting renal transplants, suggesting that hypoxia may be the cause of the renal damage and enzyme release. More marginal increases in isoenzyme forms were found in urine of patients with renal impairment and nephrotic syndrome.
已对肾病患者、肾移植稳定和排斥患者以及术后患者尿液中的N-乙酰-β-D-氨基葡萄糖苷酶（NAG）同工酶形式进行了研究。除了总尿NAG排泄量增加作为肾损伤指标外，该酶中间同工酶形式的百分比也出现了变化，其中主要手术后患者尿液中的增加最为明显。在一些肾移植排斥患者中也发现了类似变化，这表明缺氧可能是肾损伤和酶释放的原因。在肾功能损害和肾病综合征患者的尿液中，同工酶形式的增加更为轻微。
