肾病患者的尿N-乙酰-β-D-氨基葡萄糖苷酶活性
Urinary N-acetyl- beta-D-glucosaminidase activities in patients with renal disease.
作者信息
Wellwood J M, Ellis B G, Price R G, Hammond K, Thompson A E, Jones N F
出版信息
Br Med J. 1975 Aug 16;3(5980):408-11. doi: 10.1136/bmj.3.5980.408.
Abstract
Urinary N-acetyl-beta-D-glucosaminidase (NAG) activities were assayed in every urine void throughout 24 hours in 17 normal people and in four patients with renal disease. The variation in NAG activity due to changing rates of urine flow was almost eliminated by factoring enzyme activity by the urinary creatinine concentration. Random samples of urine may thus be used for assay. The results of NAG assay in 36 patients with acute and chronic renal diseases showed that NAG was a sensitive indicator of renal damage. This simple test may be valuable in detecting or monitoring renal disease.
摘要
对17名正常人和4名肾病患者在24小时内每次排尿的尿液进行了N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性检测。通过将酶活性除以尿肌酐浓度，几乎消除了因尿流率变化导致的NAG活性变化。因此，随机尿液样本可用于检测。对36例急慢性肾病患者的NAG检测结果表明，NAG是肾损伤的敏感指标。这项简单的检测在检测或监测肾病方面可能具有重要价值。
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