Hallé P, Paré P, Kaptein E, Kanel G, Redeker A G, Reynolds T B
Gastroenterology. 1982 May;82(5 Pt 1):925-31.
Sixty-seven patients entered a double-blind, controlled trial to evaluate the efficacy of propylthiouracil treatment in severe alcoholic hepatitis. Twenty-three percent (7 of 31) given propylthiouracil and 19% (7 of 36) given placebo died during the 6-wk study. Propylthiouracil treatment did not reduce the frequency and incidence of complications in alcoholic hepatitis, but induced hypothyroidism in 4 patients. Treatment produced no beneficial effect on any of the hepatic biochemical tests. We were unable to show any beneficial effect of propylthiouracil treatment on morbidity and mortality in patients with severe acute alcoholic hepatitis.
67名患者进入一项双盲对照试验，以评估丙硫氧嘧啶治疗重症酒精性肝炎的疗效。在为期6周的研究中，服用丙硫氧嘧啶的患者中有23%（31例中的7例）死亡，服用安慰剂的患者中有19%（36例中的7例）死亡。丙硫氧嘧啶治疗并未降低酒精性肝炎并发症的发生频率和发生率，但有4例患者出现了甲状腺功能减退。该治疗对任何肝脏生化检查均无有益作用。我们未能证明丙硫氧嘧啶治疗对重症急性酒精性肝炎患者的发病率和死亡率有任何有益作用。
