Lindsay V J, Allardyce R A
Immunology. 1982 Mar;45(3):423-30.
Natural killer (NK) cell cytotoxic activity is thought to operate as an early defence system before the expression of specific cytotoxic immune effectors (Leibold & Peter, 1978). Apart from this temporal relationship it is likely that other mechanisms exist to regulate these two forms of host defence and their relationship to one another. Present studies firstly substantiate evidence that normal and immune effector cells represent different cell types even though they share many functional characteristics in vitro. Normal effector cells (NEC) cytotoxic for normal dermal-derived fibroblasts in vitro were present in rats 3-36 weeks old, were tissue-dependent (with low levels in lymph nodes and thymus, unrelated to cellular suppression), were nylon wool and glass non-adherent and sensitive to 400 rad of X-irradiation in vitro. Secondly, discrimination between normal and immune cell-mediated cytotoxicity by factor(s) present in normal rat serum (Lindsay & Allardyce, 1981) allowed various aspects of their in vitro and in vivo relationship to be examined. These studies suggested that the expression of NEC cytotoxicity was temporally related to the in vivo generation of immune cytotoxic effector cells.
自然杀伤（NK）细胞的细胞毒性活性被认为在特异性细胞毒性免疫效应器表达之前作为一种早期防御系统发挥作用（莱博尔德和彼得，1978年）。除了这种时间关系外，可能还存在其他机制来调节这两种宿主防御形式及其相互关系。目前的研究首先证实，正常效应细胞和免疫效应细胞代表不同的细胞类型，尽管它们在体外具有许多共同的功能特征。体外对正常真皮来源的成纤维细胞具有细胞毒性的正常效应细胞（NEC）存在于3至36周龄的大鼠中，具有组织依赖性（在淋巴结和胸腺中水平较低，与细胞抑制无关），不粘附尼龙毛和玻璃，并且在体外对400拉德的X射线照射敏感。其次，通过正常大鼠血清中存在的因子区分正常和免疫细胞介导的细胞毒性（林赛和阿拉迪斯，1981年），使得能够研究它们在体外和体内关系的各个方面。这些研究表明，NEC细胞毒性的表达在时间上与免疫细胞毒性效应细胞的体内生成有关。
