Russell G I, Bing R F, Thurston H, Swales J D
Hypertension. 1982 Jan-Feb;4(1):69-76. doi: 10.1161/01.hyp.4.1.69.
Conscious rats with two-kidney one clip Goldblatt hypertension had the constricting clip removed during continuous infusion of either dextrose, saralasin, or captopril. Other dextrose-infused animals underwent removal of the ischemic kidney or a sham procedure. Direct arterial blood pressure (BP) was recorded throughout the 15-hour preoperative and subsequent 24-hour postoperative period. Rats were studied in the "early" phase (1-3 weeks duration) or "chronic" phase (greater than 4 months) of hypertension. Animals subjected to a sham procedure returned to preoperative BP values. The BP of animals unclipped or nephrectomized did not return to previous hypertensive levels. Instead, a biphasic response was seen where BP partially recovered from an operative fall and then slowly declined to normal at 24 hours; this effect occurred in both stages of hypertension. At 24 hours, removal of the ischemic kidney was as effective as removal of the constricting clip in the correction of both early and chronic phase hypertension. Rats infused with saralasin or captopril demonstrated an acute (within 2 hours) and sustained fall in BP, but not to normotensive levels. This fall was significant in all animals (p less than 0.01) apart from chronic phase rats infused with saralasin where no significant fall was seen. Although animals infused with saralasin or captopril commenced at a lower preoperative BP, the biphasic pattern of response to unclipping was identical to that of dextrose-infused unclipped rats. Thus, sustained inhibition of the renin-angiotensin system did not modify the correction of hypertension produced by removal of the constricting clip, and the response to surgical correction did not appear to be entirely mediated by changes in the activity of the renin-angiotensin system, particularly in the chronic stage. Equally, the rapidity of correction is not consistent with a role of vascular hypertrophy.
在持续输注葡萄糖、沙拉新或卡托普利的过程中，对患有两肾一夹型戈德布拉特高血压的清醒大鼠移除其缩窄夹。其他输注葡萄糖的动物则接受缺血肾切除或假手术。在术前15小时及术后随后的24小时期间持续记录直接动脉血压（BP）。在高血压的“早期”阶段（持续1 - 3周）或“慢性”阶段（超过4个月）对大鼠进行研究。接受假手术的动物血压恢复到术前水平。未夹闭或接受肾切除的动物血压未恢复到先前的高血压水平。相反，出现了双相反应，即血压从手术引起的下降中部分恢复，然后在24小时时缓慢降至正常；这种效应在高血压的两个阶段均出现。在24小时时，切除缺血肾在纠正早期和慢性期高血压方面与移除缩窄夹同样有效。输注沙拉新或卡托普利的大鼠血压出现急性（2小时内）且持续下降，但未降至正常血压水平。除了输注沙拉新的慢性期大鼠未见明显下降外，所有动物的这种下降均具有显著性（p < 0.01）。尽管输注沙拉新或卡托普利的动物术前血压较低，但对夹闭解除的双相反应模式与输注葡萄糖的未夹闭大鼠相同。因此，持续抑制肾素 - 血管紧张素系统并未改变移除缩窄夹所产生的高血压的纠正情况，并且对手术纠正的反应似乎并非完全由肾素 - 血管紧张素系统活性的变化介导，尤其是在慢性阶段。同样，纠正的快速性与血管肥大的作用不一致。
