Swales J D, Bing R F, Russell G I, Thurston H
Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):239-51. doi: 10.1111/j.1440-1681.1983.tb00191.x.
The fall in blood pressure observed in both early and chronic phase Goldblatt 2-kidney 1-clip hypertension produced by removing or unclipping the ischaemic kidney is due to a profound fall in peripheral resistance. The two procedures have an equal effect upon peripheral resistance and the lesser efficacy of nephrectomy in lowering blood pressure is due to a greater rise in stroke volume perhaps associated with a greater degree of sodium retention. Neither changes in sodium balance, in the renin-angiotensin system nor in vascular reactivity explain the fall in blood pressure. A reduction in renal sympathetic afferent activity and a medullary based vasoactive humoral system may play a role although the nature and extent of that role remain to be defined.
在早期和慢性期的Goldblatt二肾一夹高血压模型中，通过切除或松开缺血肾所观察到的血压下降，是由于外周阻力的显著降低。这两种操作对外周阻力的影响相同，而肾切除术在降低血压方面效果较差，是因为心搏量的增加幅度更大，这可能与钠潴留程度更高有关。钠平衡、肾素-血管紧张素系统或血管反应性的变化均不能解释血压下降的原因。肾交感传入神经活动的降低和基于髓质的血管活性体液系统可能起了作用，尽管该作用的性质和程度尚待确定。
