脱氧胆酸钠在构巢曲霉中诱导的有丝分裂非整倍体。

Mitotic aneuploidy induced by sodium deoxycholate in Aspergillus nidulans.

作者信息

Assinder S J, Upshall A

出版信息

Mutat Res. 1982 Mar;93(1):101-8. doi: 10.1016/0027-5107(82)90128-2.

Abstract

Sodium deoxycholate is shown to induce aneuploidy in a heterozygous diploid strain of Aspergillus nidulans. It is suggested that this is the result of interference with the normal functioning of the mitotic apparatus through disruption of the nuclear membrane. This effect limits the value of sodium deoxycholate as a paramorphogenic agent in the estimation of the genotoxic effects of environmental and genetic factors.

摘要

已表明脱氧胆酸钠可在构巢曲霉的杂合二倍体菌株中诱导非整倍体。有人认为，这是由于核膜破裂干扰了有丝分裂装置的正常功能所致。这种效应限制了脱氧胆酸钠作为一种副形态发生剂在评估环境和遗传因素的遗传毒性效应方面的价值。