Isobe M, Yano K
Mutat Res. 1982 Mar;93(1):57-66. doi: 10.1016/0027-5107(82)90125-7.
The mutagenic activities of 11 N-methyl-N'-alkyl-N-nitrosoureas were tested on Salmonella typhimurium TA1535 and compared with chemical properties (alkylating activity and decomposition rate). In their relative mutagenicities the N-nitrosoureas that had a cyclic N'-alkyl groups showed far more mutagenic activity than those having a chain N;-alkyl group. M(1-A) NU and M(2-A)NU, which had the most bulky N'-alkyl group in this series, exhibited lethal effects at high concentrations. The mutagenicity showed a small positive correlation with decomposition rates but not with alkylating activities on 4-(p-nitrobenzyl)pyridine. The highest mutagenicity in this series was observed in N-methyl-N'cyclobutyl-N-nitrosourea. These results suggest that, in this series of N-methyl-N'-alkyl-N-nitrosoureas, structural differences in the N'-alkyl groups had great significance in mutagenicity.
在鼠伤寒沙门氏菌TA1535上测试了11种N-甲基-N'-烷基-N-亚硝基脲的诱变活性，并与化学性质（烷基化活性和分解速率）进行了比较。在它们的相对诱变性方面，具有环状N'-烷基的N-亚硝基脲显示出比具有链状N'-烷基的N-亚硝基脲高得多的诱变活性。在该系列中具有最大体积N'-烷基的M(1-A) NU和M(2-A)NU在高浓度下表现出致死效应。诱变性与分解速率呈小的正相关，但与对4-(对硝基苄基)吡啶的烷基化活性无关。在该系列中，N-甲基-N'-环丁基-N-亚硝基脲的诱变性最高。这些结果表明，在该系列N-甲基-N'-烷基-N-亚硝基脲中，N'-烷基的结构差异对诱变性具有重要意义。
