Revuelta A V, Moroni F, Cheney D L, Costa E
Naunyn Schmiedebergs Arch Pharmacol. 1978 Sep;304(2):107-10. doi: 10.1007/BF00495546.
The effects of delta9-tetrahydrocannabinol (delta9-THC), the major psychoactive compound of marijuana, and cannabidiol (CBD), a non-psychoactive component, on the acetylcholine (ACh) concentration and the turnover rate of ACh (TRACh) have been studied in various regions of the rat brain. Neither delta9-THC doses from 0.2 to 10 mg/kg nor CBD (10 OR 20 MG/KG) alter the ACh concentration in the brain areas examined 30 min, after the intravenous injection. However, delta9-THC (doses from 0.2 to 10 mg/kg) causes a marked dose-related decrease in the TRACh in hippocampus whereas CBD is without effect in this brain region even when 20 mg/kg is given. Furthermore, high doses of delta9-THC (5 mg/kg) and CBD (20 mg/kg) that produce a significant decrease in the TRACh of striatum fail to change the TRACh in parietal cortex. The low doses of delta9-THC required to reduce hippocampal TRACh suggest that an action on these cholinergic mechanisms may play a role in the psychotomimetic activity of delta9-THC.
大麻的主要精神活性成分Δ⁹-四氢大麻酚（Δ⁹-THC）和非精神活性成分大麻二酚（CBD）对大鼠脑不同区域乙酰胆碱（ACh）浓度及ACh周转率（TRACh）的影响已得到研究。静脉注射后30分钟，0.2至10mg/kg的Δ⁹-THC剂量以及10或20mg/kg的CBD均未改变所检测脑区的ACh浓度。然而，0.2至10mg/kg剂量的Δ⁹-THC可导致海马体中TRACh显著的剂量相关降低，而即使给予20mg/kg的CBD，在该脑区也无作用。此外，能使纹状体TRACh显著降低的高剂量Δ⁹-THC（5mg/kg）和CBD（20mg/kg）未能改变顶叶皮质的TRACh。降低海马体TRACh所需的低剂量Δ⁹-THC表明，对这些胆碱能机制的作用可能在Δ⁹-THC的拟精神病活性中起作用。
