Abstract
Ninety insulin-dependent diabetic children were HLA-typed in order to elucidate the role played by HLA complex-linked genes in the pathogenesis of diabetes mellitus of childhood. HLA-Aw30 and HLA-Bw35 were significantly increased and decreased, respectively, in the diabetic group as compared with controls. In relation to age at onset of diabetes, HLA-B8 was significantly increased in the 0-5-year group. By dividing the patients according to the season at onset of the disease, only HLA-Aw30 in the October-January group reached the level of significance.
摘要
对90名胰岛素依赖型糖尿病儿童进行了HLA分型，以阐明HLA复合体相关基因在儿童糖尿病发病机制中所起的作用。与对照组相比，糖尿病组中HLA-Aw30显著增加，而HLA-Bw35显著减少。关于糖尿病发病年龄，0-5岁组中HLA-B8显著增加。根据疾病发病季节对患者进行分组，只有10月至1月组中的HLA-Aw30达到显著水平。
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引用本文的文献
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Juvenile diabetes mellitus: possibility of prevention.青少年糖尿病：预防的可能性。
Arch Dis Child. 1979 Aug;54(8):569-80. doi: 10.1136/adc.54.8.569.
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