青少年型糖尿病中抗胰岛素免疫遗传控制的证据。
Evidence for genetic control of anti-insulin immunity in juvenile onset diabetes mellitus.
作者信息
Schernthaner G, Ludwig H, Mayr W R, Frisch H
出版信息
Diabete Metab. 1977 Jun;3(2):117-21.
The role of genetic factors in humoral anti-insulin-response was studied in 87 patients with juvenile onset diabetes. A significant insulin antibody formation was found in 76 (87%) juvenile diabetics. By dividing these patients in four groups according to different heights of insulin antibody levels (non-, low-, moderate- and high-responders) a positive or negative correlation between humoral anti-insulin response and certain HLA antigens could be found. Non-responders showed a close association with HLA-B7 positivity, whereas in the insulin high-responder patients, a considerable decrease of HLA-B8 and increase of HLA-Bw15 and HLA-Cw3 was found. These findings indicate that certain genetic constellations within the HLA complex might have an important part in determining humoral anti-insulin immunity.
对87例青少年起病的糖尿病患者研究了遗传因素在体液抗胰岛素反应中的作用。在76例（87%）青少年糖尿病患者中发现有明显的胰岛素抗体形成。根据胰岛素抗体水平的不同高度将这些患者分为四组（无反应者、低反应者、中度反应者和高反应者），发现体液抗胰岛素反应与某些HLA抗原之间存在正相关或负相关。无反应者与HLA - B7阳性密切相关，而在胰岛素高反应患者中，发现HLA - B8显著减少，HLA - Bw15和HLA - Cw3增加。这些发现表明，HLA复合体中的某些基因组合可能在决定体液抗胰岛素免疫方面起重要作用。
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