Skinner J M, Whitehead R
Virchows Arch A Pathol Anat Histol. 1981;394(1-2):109-18. doi: 10.1007/BF00431669.
The presence of carcinoplacental alkaline phosphatase (CP Alk P) was demonstrated in the cells of malignant and premalignant states of the human stomach, colon and rectum using the immunoperoxidase technique. It was shown to be present in 7 out of 18 carcinomas of stomach and 7 of 17 cases of carcinoma of colon and rectum. In the putative premalignant states it was demonstrated in 4 of 15 cases of intestinal metaplasia associated with gastric carcinoma, and 9 of 12 tubulovillous adenomas of colon. However, it was also demonstrated in 5 of 8 metaplastic polyps of colon which are not neoplastic and in 9 of 17 cases of intestinal metaplasia not associated with cancer of the stomach. It was not seen in normal gastric mucosa and only faintly in 1 of 11 samples of normal colon. CP Alk P has been shown to be a specific marker of malignancy in a wide range of human cancers when studied in sera from patients or in tissue culture of tumour cells. In this study however, although a statistical difference exists between normal and diseased tissue the marker appears as frequently in non-neoplastic states. It is concluded that CP Alk P is, in tissues, a marker of proliferative activity in cells, rather than neoplastic or malignant change. In this respect it is similar in some respects to carcinoembryonic antigen, but not other markers of placental origin such as pregnancy specific beta, glycoprotein.
采用免疫过氧化物酶技术，在人胃、结肠和直肠的恶性及癌前状态细胞中证实了癌胎盘碱性磷酸酶（CP Alk P）的存在。结果显示，在18例胃癌中有7例、17例结直肠癌中有7例存在该酶。在假定的癌前状态中，在15例与胃癌相关的肠化生中有4例、12例结肠管状绒毛状腺瘤中有9例检测到该酶。然而，在8例非肿瘤性结肠化生息肉中有5例、17例与胃癌无关的肠化生中有9例也检测到该酶。在正常胃黏膜中未检测到该酶，在11例正常结肠样本中仅有1例呈弱阳性。当在患者血清或肿瘤细胞组织培养中进行研究时，CP Alk P已被证明是多种人类癌症中恶性肿瘤的特异性标志物。然而，在本研究中，尽管正常组织和病变组织之间存在统计学差异，但该标志物在非肿瘤状态中也经常出现。结论是，在组织中，CP Alk P是细胞增殖活性的标志物，而非肿瘤或恶性变化的标志物。在这方面，它在某些方面与癌胚抗原相似，但与其他胎盘来源的标志物如妊娠特异性β糖蛋白不同。
