Saakian I R, Karapetian T D
Vopr Med Khim. 1981 Nov-Dec;27(6):755-9.
Alterations in coupling of respiration and phosphorylation as well as in energy-dependent transport of calcium in liver mitochondria of recipient were studied in dynamics of antigenic response to rat heart transplantation. As compared with the normal state the reactions studied varied in opposite directions, towards activation (hyperergic step) within 1-4 days after the heart transplantation and to decrease in their activity (hyperergic step) within 6-10 days; the latter period was characterized by development of the state similar to pathological one. Increased in amount of endogenous succinic acid as well as in succinate dehydrogenase activity were apparently among the other factors responsible for activation of energy metabolism in the hyperergic state. The reactions of liver mitochondria studied were identified as unspecific adaptation of the recipient liver tissue, which might be used for diagnosis of early steps of rejection crisis.
在大鼠心脏移植抗原反应动态过程中，研究了受体肝脏线粒体中呼吸与磷酸化偶联以及钙的能量依赖性转运的变化。与正常状态相比，所研究的反应呈相反方向变化，在心脏移植后1 - 4天内朝着激活方向（高反应性阶段）变化，而在6 - 10天内其活性降低（低反应性阶段）；后一时期的特征是发展出类似于病理状态的情况。内源性琥珀酸量的增加以及琥珀酸脱氢酶活性的增加显然是导致高反应性状态下能量代谢激活的其他因素之一。所研究的肝脏线粒体反应被确定为受体肝脏组织的非特异性适应性反应，可用于排斥危机早期阶段的诊断。
