[急性肾衰竭大鼠肝脏线粒体的功能状态]
[Functional state of the rat liver mitochondria in acute kidney failure].
作者信息
Khakimov Z Z, Krakovskiĭ M E, Inoiatova F Kh
出版信息
Vopr Med Khim. 1984 Jan-Feb;30(1):29-32.
PMID:6324486
Abstract
Activity of mitochondrial enzymes, respiration and oxidative phosphorylation in liver mitochondria were studied in rats with acute kidney insufficiency caused by bilateral nephrectomy. Depending on severity of kidney insufficiency, distinct alterations were observed in the functional state of animal mitochondria, especially during the low energetic shifting even down to uncoupling of respiration and oxidative phosphorylation; the phenomenon appears to be one of reasons of liver tissue failure in uremia.
摘要
对双侧肾切除所致急性肾功能不全大鼠的肝线粒体中的线粒体酶活性、呼吸及氧化磷酸化进行了研究。根据肾功能不全的严重程度，在动物线粒体的功能状态中观察到明显改变，尤其是在能量转换较低时，甚至出现呼吸与氧化磷酸化解偶联；该现象似乎是尿毒症时肝组织衰竭的原因之一。
相似文献
1
[Functional state of the rat liver mitochondria in acute kidney failure].[急性肾衰竭大鼠肝脏线粒体的功能状态]
Vopr Med Khim. 1984 Jan-Feb;30(1):29-32.
2
[Functional state of rat liver mitochondria in experimental peritonitis].[实验性腹膜炎大鼠肝脏线粒体的功能状态]
Vopr Med Khim. 1984 Jul-Aug;30(4):97-100.
3
Methotrexate: studies on the cellular metabolism. I. Effect on mitochondrial oxygen uptake and oxidative phosphorylation.甲氨蝶呤：细胞代谢研究。I. 对线粒体氧摄取和氧化磷酸化的影响。
Cell Biochem Funct. 1988 Jan;6(1):61-6. doi: 10.1002/cbf.290060110.
4
[Effect of o-p'-DDD on oxidative phosphorylation in mitochondria of liver and kidney in guinea pigs].[邻对二氯二苯二氯乙烷对豚鼠肝脏和肾脏线粒体氧化磷酸化的影响]
Ukr Biokhim Zh. 1970;42(4):459-63.
5
[Dynamics of the changes of reaction of hepatic mitochondria in congestive circulatory insufficiency].
Patol Fiziol Eksp Ter. 1975 Nov-Dec(6):32-7.
6
Influence of increased environmental temperature on oxidation processes in rat liver mitochondria.环境温度升高对大鼠肝脏线粒体氧化过程的影响。
Acta Physiol Pol. 1986 Jul-Aug;37(4-5):157-67.
7
Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation.农达和草甘膦对线粒体氧化磷酸化的比较效应。
Chemosphere. 2005 Dec;61(8):1115-22. doi: 10.1016/j.chemosphere.2005.03.044. Epub 2005 Apr 26.
8
[Cytology and biochemistry of the mitochondria of regenerating liver].
Usp Sovrem Biol. 1978 Jul-Aug;86(1):114-28.
9
Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.生长迟缓大鼠肝脏线粒体中氧化磷酸化受损。
Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1258-66. doi: 10.1152/ajpendo.00437.2002.
Zotero 插件