Hedeboe J, Buhl M, Ramsing P
Acta Neurol Scand. 1982 Jan;65(1):6-10. doi: 10.1111/j.1600-0404.1982.tb03055.x.
Previous reports concerning the treatment of symptoms deriving from prolapsed lumbar disc with systemic administration of the potent steroid dexamethasone, have shown favourable results. The present clinical study includes 39 patients with symptoms of prolapsed lumbar disc, treated in a controlled double-blind investigation with dexamethasone or placebo. Twenty patients had provable effect of the treatment, 19 had no effect. Nineteen patients received dexamethasone (13 + effect), 20 received placebo (7 + effect). The groups were fully comparable, and the difference is not statistically significant. During a period of 3 months 50% of the patients who improved by the treatment of either group had recurrences leading to operation. It is concluded that the effect of dexamethasone given intramuscularly does not seem to exceed that of placebo in the treatment of prolapsed lumbar disc.
先前有关通过全身给药强效类固醇地塞米松来治疗腰椎间盘突出所致症状的报告显示出了良好效果。本临床研究纳入了39例有腰椎间盘突出症状的患者，在一项对照双盲研究中用地塞米松或安慰剂进行治疗。20例患者治疗有明显效果，19例无效。19例患者接受地塞米松治疗（13例有效果），20例接受安慰剂治疗（7例有效果）。两组具有充分可比性，差异无统计学意义。在3个月的时间里，两组中经治疗病情改善的患者有50%复发并需要手术。得出的结论是，在治疗腰椎间盘突出方面，肌肉注射地塞米松的效果似乎并不超过安慰剂。
