Manniche C, Lauritsen B, Vinterberg H
Dept. of Rheumatology, Hillerød Hospital, Denmark.
Scand J Rheumatol. 1994;23(1):30-5. doi: 10.3109/03009749409102132.
Ninety three patients undergoing their first conventional hemilaminectomy for lumbar disc protusion were randomized to a double blind clinical trial. Half of the patients were treated immediately following surgery with prednisolone; 50 mg per day for fourteen days and then 25 mg per day for another 14 days. The other patients were treated for the same time period with placebo tablets. Assessments using subjective and objective outcome criteria at 26 weeks, 52 weeks and 156 weeks of follow-up, demonstrated no statistically significant differences between the randomized groups. It is concluded that systemic prednisolone administration in the pre- and postoperative period does not in this study improve the clinical outcome after first time lumbar discectomy.
93例因腰椎间盘突出症首次接受传统半椎板切除术的患者被随机分配至一项双盲临床试验。一半患者在术后立即接受泼尼松龙治疗；每天50毫克，持续14天，然后每天25毫克，再持续14天。另一半患者在相同时间段内服用安慰剂片。在随访26周、52周和156周时使用主观和客观结果标准进行评估，结果显示随机分组的两组之间无统计学显著差异。得出的结论是，在本研究中，术前和术后全身给予泼尼松龙并不能改善首次腰椎间盘切除术后的临床结果。
