Allen I V, Millar J H, Hutchinson M J
Neuropathol Appl Neurobiol. 1978 Jul-Aug;4(4):279-84. doi: 10.1111/j.1365-2990.1978.tb00546.x.
The general pathology in 120 necropsy-proven cases of multiple sclerosis has been compared with that of matched neurological and general controls. There was no significant difference in the incidence of coronary thrombosis, myocardial infarction, cerebral haemorrhage, thyroid atrophy and splenic haemosiderosis. There was also no significant difference in malignancy in the three groups. The implications of these findings with particular reference to immunopathology are discussed. 74% of patients with multiple sclerosis died from complications of the disease; 26% died from apparently unrelated diseases.
对120例经尸检证实的多发性硬化症病例的一般病理学与匹配的神经学和一般对照病例进行了比较。冠状动脉血栓形成、心肌梗死、脑出血、甲状腺萎缩和脾含铁血黄素沉着症的发生率没有显著差异。三组中的恶性肿瘤发生率也没有显著差异。讨论了这些发现特别是与免疫病理学相关的意义。74%的多发性硬化症患者死于该疾病的并发症；26%死于明显无关的疾病。
