Adams C W
Division of Histopathology, United Medical School of Guy's Hospital, University of London, UK.
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):260-5. doi: 10.1136/jnnp.51.2.260.
Evidence of damage to cerebral vein walls was sought in 70 cases of multiple sclerosis. Seventy control cases were also examined. The multiple sclerosis cases showed venous intramural fibrinoid deposition (7%), recent haemorrhages (17%), old haemorrhages revealed by haemosiderin deposition (30%), thrombosis (6%) and thickened veins (19%). In all, 41% of all multiple sclerosis cases showed some evidence of vein damage. Occasional control cases showed haemosiderin deposition in the brain but, unlike the multiple sclerosis cases, these were diffuse and almost entirely related to coexistent cardiovascular or cerebrovascular disease. Haemosiderin deposition was common in the substantia nigra and other pigmented nuclei in all cases. It is concluded that the cerebral vein wall in multiple sclerosis is subject to chronic inflammatory damage, which promotes haemorrhage and increased permeability, and constitutes a form of vasculitis.
在70例多发性硬化症患者中探寻脑静脉壁损伤的证据。同时检查了70例对照病例。多发性硬化症病例显示静脉壁内纤维蛋白样沉积（7%）、近期出血（17%）、含铁血黄素沉积显示的陈旧性出血（30%）、血栓形成（6%）以及静脉增厚（19%）。总体而言，所有多发性硬化症病例中有41%显示出静脉损伤的某些证据。偶尔有对照病例显示大脑中有含铁血黄素沉积，但与多发性硬化症病例不同的是，这些沉积是弥漫性的，几乎完全与并存的心血管或脑血管疾病有关。在所有病例中，含铁血黄素沉积在黑质和其他色素核中很常见。得出的结论是，多发性硬化症中的脑静脉壁受到慢性炎症损伤，这会促进出血和通透性增加，并构成一种血管炎形式。
