Burke J S
Am J Surg Pathol. 1981 Oct;5(7):681-94.
The diseases which chiefly pertain to the differential diagnosis of splenic lymphomas and leukemias primarily involving the red pulp have been separated into five histologic categories. These include the various forms of congestion, infections, benign and malignant histiocytic proliferations, leukemias and myeloproliferative disorders, and the rare nonhematopoietic tumors of the spleen. Many diseases with major involvement of the red pulp present as hypersplenism of unknown etiology. Accurate diagnosis is particularly dependent on an awareness of the specific histologic manifestations of malignant histiocytosis and the different leukemias in contrast to benign disorders, such as infectious mononucleosis which may simulate malignancy in the splenic red pulp. For each histologic category, therefore, the relevant morphologic features are reviewed, pathophysiologic mechanisms and clinical manifestations correlated, and criteria for differential diagnosis emphasized.
主要涉及红髓的脾淋巴瘤和白血病的鉴别诊断相关疾病已被分为五个组织学类别。这些包括各种形式的充血、感染、良性和恶性组织细胞增生、白血病和骨髓增殖性疾病，以及罕见的脾脏非造血肿瘤。许多主要累及红髓的疾病表现为病因不明的脾功能亢进。准确的诊断特别依赖于对恶性组织细胞增多症和不同白血病的特定组织学表现的认识，以区别于良性疾病，如可能在脾红髓中模拟恶性肿瘤的传染性单核细胞增多症。因此，对于每个组织学类别，回顾相关的形态学特征，关联病理生理机制和临床表现，并强调鉴别诊断标准。
