Roullet E, Bleichner G, Mathiot C, Varet B, Monsallier J F
Ann Med Interne (Paris). 1981;132(8):554-8.
A transient neutropenia (duration : less than 48 hours) occurred in 6 patients with severe bacterial infections. The bone marrow myeloïd cellularity was high or normal; a maturation arrest of the myeloïd cells - at a variable stage - was present in each case, as well as circulating granulocyte precursors. Other causes of neutropenia were excluded. A general survey of the literature is made and the mechanisms of this bacterial neutropenia are considered : bone marrow failure seems mostly improbable ; the few previously reported cases, the experimental bacterial neutropenias, the peculiar, transient, evolution we observed, all favor a peripheral mechanism ; the bacterial infection seems to act by; two ways : in septicemia (especially during septic shock) by enhancing leucocyte margination along vascular walls ; in large septic foci (mostly pulmonary) by an important destruction of polymorphonuclear neutrophils. Such bacterial infections share a bad prognosis but the neutropenia itself needs no specific treatment.
6例严重细菌感染患者出现短暂性中性粒细胞减少（持续时间：少于48小时）。骨髓髓细胞增多或正常；每例均存在不同阶段的髓细胞成熟停滞以及循环中的粒细胞前体。排除了其他中性粒细胞减少的原因。对文献进行了综述，并探讨了这种细菌性中性粒细胞减少的机制：骨髓衰竭似乎极不可能；先前报道的少数病例、实验性细菌性中性粒细胞减少以及我们观察到的特殊、短暂的病程，均支持外周机制；细菌感染似乎通过两种方式起作用：在败血症（尤其是感染性休克期间）通过增强白细胞沿血管壁的边缘化；在大的感染灶（主要是肺部）通过大量破坏多形核中性粒细胞。此类细菌感染预后不良，但中性粒细胞减少本身无需特殊治疗。
