The dependence potential of thebaine is at least partially attributed to oripavine which is one of the principal metabolites of thebaine. The analgesic potency of oripavine in mice is found to be much higher than that of thebaine and comparable to morphine. The reinforcing effect of this substance also appears to be more potent than thebaine. In rats the physical dependence potential of oripavine at a dose of 4 mg/kg is almost comparable to that of morphine at 0.5 mg/kg. Studies carried out on monkeys show that oripavine possesses weak morphine-antagonist properties. Further pharmacological studies of the metabolites of thebaine are recommended.
蒂巴因的成瘾潜力至少部分归因于奥里派文，它是蒂巴因的主要代谢产物之一。已发现奥里派文对小鼠的镇痛效力远高于蒂巴因，与吗啡相当。该物质的强化作用似乎也比蒂巴因更强。在大鼠中，4毫克/千克剂量的奥里派文产生身体依赖性的潜力几乎与0.5毫克/千克的吗啡相当。对猴子进行的研究表明，奥里派文具有微弱的吗啡拮抗特性。建议对蒂巴因的代谢产物进行进一步的药理学研究。
