Schneider R E
Clin Ther. 1982;4(5):390-4.
A single-blind comparison was undertaken to evaluate 250 mg of cinoxacin and 100 mg of nitrofurantoin, both drugs being given four times a day, for the treatment of urinary tract infections. Complete data are available from 58 patients, most of whom were treated for 10 to 15 days. The clinical response was similar in both treatment groups, only one patient in the nitrofurantoin group having a recurrence of symptoms in the posttreatment follow-up period. In one patient in the cinoxacin group, the pathogen was not eradicated, and two patients who received nitrofurantoin had a reinfection with a new pathogen. Four patients stopped treatment early in the study because of side effects attributed to the trial drugs (three on cinoxacin, one on nitrofurantoin). Of the patients who completed the study, only six complained of side effects (two on cinoxacin, four on nitrofurantoin). The results of this study show that cinoxacin is a useful drug for the treatment of urinary tract infection due to susceptible organisms.
进行了一项单盲比较，以评估250毫克西诺沙星和100毫克呋喃妥因治疗尿路感染的效果，两种药物均每日服用4次。58例患者有完整数据，其中大多数接受了10至15天的治疗。两个治疗组的临床反应相似，呋喃妥因组仅1例患者在治疗后随访期症状复发。西诺沙星组有1例患者病原体未被根除，接受呋喃妥因治疗的2例患者发生了新病原体的再感染。4例患者因试验药物的副作用在研究早期停止治疗（3例使用西诺沙星，1例使用呋喃妥因）。完成研究的患者中，只有6例抱怨有副作用（2例使用西诺沙星，4例使用呋喃妥因）。本研究结果表明，西诺沙星是治疗由敏感菌引起的尿路感染的有效药物。
