心脏瓣膜和成纤维细胞的Fc受体研究。
Studies of Fc receptors of heart valve and joint fibroblasts.
作者信息
Danilova T A, Bartova L M, Panurina R L, Lyampert I M
出版信息
Clin Exp Immunol. 1981 Dec;46(3):575-80.
Normal human and rabbit sera, and the IgG isolated from them, have been shown by immunofluorescence to react with bovine and human heart valve fibroblasts. Analogous results were obtained with sera of children under the age of 2. Positive reactions were observed also with fibroblasts, chondrocytes and osteocytes of human fetal joint tissues. The reactions are mostly due to monomeric immunoglobulins, since soluble immune complexes give much weaker reactions with the fibroblasts. The reactions are apparently dependent on the presence of Fc receptors on these cells. This conclusion is confirmed by positive reactions with IgG Fc fragments, with pure antibodies to ovalbumin and with human monoclonal IgG. The monoclonal IgG1 possesses the strongest ability to bind with fibroblast Fc receptors. No Fc-IgG receptors have been revealed on the fibroblasts and other structures of the interstitial connective tissue of human and bovine myocardium.
免疫荧光显示，正常人血清、兔血清及其分离出的IgG可与牛和人心脏瓣膜成纤维细胞发生反应。2岁以下儿童的血清也得到了类似结果。在人胎儿关节组织的成纤维细胞、软骨细胞和骨细胞中也观察到阳性反应。这些反应主要归因于单体免疫球蛋白，因为可溶性免疫复合物与成纤维细胞的反应要弱得多。这些反应显然取决于这些细胞上Fc受体的存在。用IgG Fc片段、抗卵清蛋白纯抗体和人单克隆IgG进行的阳性反应证实了这一结论。单克隆IgG1与成纤维细胞Fc受体结合的能力最强。在人和牛心肌间质结缔组织的成纤维细胞及其他结构上未发现Fc-IgG受体。
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