Zaroulis C G, Schweitzer R L, Barchet S, Valeri C R
Obstet Gynecol. 1978 Sep;52(3):358-60.
An anemic pregnant black primigravida with hemoglobin SD disease was studied throughout pregnancy and parturition. Hemoglobin SD disease was established by agar gel electrophoresis at pH 6.2. The patient carried to term a healthy femlae infant, an unusual occurrence in a patient homozygous for hemoglobin SD disease. The increase in the red cell concentration of 2,3 disphosphoglycerate (2,3 DPG) of 18--21 micrometer/g Hb (normal 12 +/- 2 micrometer/g Hb) was associated with a decrease in red cell oxygen affinity. The patient's in vitro P50 value ranged between 35 and 45 mm Hg (normal 28 +/- 1 mmHg). The function of red cells with increased 2,3 DPG levels and decreased affinity for oxygen in a pregnant woman with hemoglobin SD disease is discussed.
对一名患有血红蛋白SD病的贫血黑人初产妇进行了整个孕期及分娩过程的研究。血红蛋白SD病通过在pH 6.2条件下的琼脂凝胶电泳得以确诊。该患者足月产下一名健康女婴，这在血红蛋白SD病纯合子患者中是不寻常的情况。红细胞内2,3-二磷酸甘油酸（2,3-DPG）浓度增加至18 - 21微摩尔/克血红蛋白（正常为12±2微摩尔/克血红蛋白）与红细胞氧亲和力降低相关。患者的体外P50值在35至45毫米汞柱之间（正常为28±1毫米汞柱）。本文讨论了血红蛋白SD病孕妇中2,3-DPG水平升高且对氧亲和力降低的红细胞的功能。
