Hulka B S
J Chronic Dis. 1982;35(1):3-11. doi: 10.1016/0021-9681(82)90024-8.
Despite a long history of research into the epidemiology and biology of cervical carcinoma, a definitive statement about its probable causes still remains elusive. This review recognizes the population based data on high and low risk groups and summarizes the findings from numerous case-control studies which have explored the marital, sexual and reproductive factors associated with cervical cancer. Although vigorously pursued, an increased risk from oral contraceptives has not been convincingly demonstrated. A variety of venereally transmitted organisms appear to be frequent cohabitants with cervical neoplastic cells. Herpesvirus type 2 still remains the prime suspect in the complex pathogenesis of cervical neoplasia. Clinical findings, biological characteristics of the virus, serological studies and interactions of host cells and viral particles continue to stimulate the most intensive investigative efforts.
尽管对宫颈癌的流行病学和生物学进行了长期研究，但关于其可能病因的明确结论仍然难以捉摸。本综述认可了基于人群的高危和低危组数据，并总结了众多病例对照研究的结果，这些研究探讨了与宫颈癌相关的婚姻、性和生殖因素。尽管大力开展研究，但口服避孕药会增加风险这一点尚未得到令人信服的证实。多种性传播病原体似乎经常与宫颈肿瘤细胞共存。在宫颈肿瘤形成的复杂发病机制中，2型疱疹病毒仍然是主要怀疑对象。临床发现、病毒的生物学特性、血清学研究以及宿主细胞与病毒颗粒的相互作用，继续激发着最深入的调查研究工作。
