Usami M, Seino Y, Seino S, Takemura J, Nakahara H, Ikeda M, Imura H
J Nutr. 1982 Apr;112(4):681-5. doi: 10.1093/jn/112.4.681.
The effects of a high protein diet on blood glucose, insulin, and glucagon secretion was studied in the peripheral blood and isolated perfused pancreas of normal rats. A balanced diet (protein 27%, carbohydrate 61%, fat 12%) and a high protein diet (protein 55%, carbohydrate 30%, fat 15%) were given ad libitum to normal rats for 2 weeks. No significant difference in calorie intake or body weight changes were observed between the two groups. Fasting blood glucose and plasma insulin concentrations in rats fed the high protein diet were significantly higher than those in rats fed the balanced diet. The fasting plasma glucagon concentration, however, was the same in both groups. In the isolated perfused pancreas, the arginine-induced insulin secretion in rats fed the high protein diet was significantly higher than that in rats fed the balanced diet, whereas the arginine-induced glucagon secretion was not different in either group. The possible mechanism by which a high protein diet causes hypersecretion of insulin in vivo and in vitro are discussed.
在正常大鼠的外周血和离体灌注胰腺中研究了高蛋白饮食对血糖、胰岛素和胰高血糖素分泌的影响。将正常大鼠随意喂食平衡饮食（蛋白质27%、碳水化合物61%、脂肪12%）和高蛋白饮食（蛋白质55%、碳水化合物30%、脂肪15%）2周。两组之间在热量摄入或体重变化方面未观察到显著差异。喂食高蛋白饮食的大鼠空腹血糖和血浆胰岛素浓度显著高于喂食平衡饮食的大鼠。然而，两组的空腹血浆胰高血糖素浓度相同。在离体灌注胰腺中，喂食高蛋白饮食的大鼠精氨酸诱导的胰岛素分泌显著高于喂食平衡饮食的大鼠，而精氨酸诱导的胰高血糖素分泌在两组中无差异。讨论了高蛋白饮食在体内和体外导致胰岛素分泌过多的可能机制。
