Wheaton J E, Mullett M A
J Reprod Fertil. 1982 Mar;64(2):325-8. doi: 10.1530/jrf.0.0640325.
Anoestrous and ovariectomized sheep were treated with progesterone-containing implants or left as controls. Plasma LH concentrations were decreased by progesterone treatment (P less than 0.025) and increased by ovariectomy (P less than 0.001). When the ewes were treated with 0.25 micrograms LH-RH, the LH response was reduced (P less than 0.025) in the progesterone-treated anoestrous ewes but not in the progesterone-treated ovariectomized sheep. These data demonstrate that low concentrations of progesterone, acting together with another ovarian hormone, can markedly reduce the pituitary response to a small dose of LH-RH.
对处于乏情期和已切除卵巢的绵羊，分别用含孕酮的植入物进行处理或留作对照。孕酮处理可使血浆促黄体生成素（LH）浓度降低（P<0.025），而切除卵巢则使其升高（P<0.001）。当给母羊注射0.25微克促性腺激素释放激素（LH-RH）时，经孕酮处理的乏情期母羊的LH反应降低（P<0.025），但经孕酮处理的切除卵巢的绵羊则没有这种情况。这些数据表明，低浓度的孕酮与另一种卵巢激素共同作用时，可显著降低垂体对小剂量LH-RH的反应。
