Wright P J, Jenkin G, Heap R B, Walters D E
J Reprod Fertil. 1978 Mar;52(2):343-8. doi: 10.1530/jrf.0.0520343.
Pituitary responsiveness to 200 microgram synthetic LH-RH and to 10 microgram TRH was determined in anoestrous sheep before and after treatment for 3 weeks with progesterone (100 mg/day), or oestradiol (250 microgram/day) plus progesterone (100 mg/day). There was a marked decrease in pituitary responsiveness to LH-RH after progesterone (P is less than 0.01), or oestradiol plus progesterone (P is less than 0.01) treatments, and an increase in response to TRH after oestradiol plus progesterone (P is less than 0.01) treatment. The results demonstrate selective and simultaneous feedback effects of oestradiol and progesterone on pituitary responsiveness to two hypothalamic releasing hormones.
测定了处于乏情期的绵羊在接受孕酮（100毫克/天）或雌二醇（250微克/天）加孕酮（100毫克/天）治疗3周前后，垂体对200微克合成促黄体激素释放激素（LH - RH）和10微克促甲状腺激素释放激素（TRH）的反应性。孕酮治疗后（P＜0.01）或雌二醇加孕酮治疗后（P＜0.01），垂体对LH - RH的反应性显著降低；雌二醇加孕酮治疗后（P＜0.01），垂体对TRH的反应性增加。结果表明，雌二醇和孕酮对垂体对两种下丘脑释放激素的反应性具有选择性且同时存在反馈作用。
