66例肾移植受者的环孢素A肝毒性
Cyclosporin A hepatotoxicity in 66 renal allograft recipients.
作者信息
Klintmalm G B, Iwatsuki S, Starzl T E
出版信息
Transplantation. 1981 Dec;32(6):488-9. doi: 10.1097/00007890-198112000-00007.
Abstract
Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A. The complication was less frequent than that of nephrotoxicity, was as easily manageable with reductions in the cyclosporin A dosage, and generally did not cause clinical illness. In an occasional case, late hepatotoxicity can force a therapeutic change from cyclosporin A to azathioprine, but careful consideration should be given to the dangers of subsequent rejection.
摘要
在接受环孢素A和泼尼松治疗的66例尸体肾移植受者中，有13例（19.7%）出现肝功能异常。然而，这种推测的肝毒性在环孢素A的使用中是一个小问题。该并发症的发生率低于肾毒性，通过减少环孢素A剂量很容易控制，并且一般不会引起临床疾病。在个别情况下，晚期肝毒性可能迫使治疗从环孢素A改为硫唑嘌呤，但应仔细考虑随后发生排斥反应的风险。
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本文引用的文献
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The use of cyclosporin A and prednisone in cadaver kidney transplantation.环孢素A和泼尼松在尸体肾移植中的应用。
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