Ungar H, Adler J H
Vet Pathol. 1982 May;19(3):230-8. doi: 10.1177/030098588201900302.
The gallbladders of 256 fat sand rats (131 males and 125 females) seven to 41 months old were studied histologically. None of the sand rats had been used in experimental procedures prior to death. Diffuse polypoid hyperplasia or papilloma of the gallbladder mucosa was found in 49 sand rats. Of these lesions, 45 were present in 126 sand rats in the second half of their lifespan. Neither concretions nor signs of chronic inflammation were seen. Signs of focal epithelial growth activity were seen in either form of lesion. Epithelial hyperplasia was excessive in two gallbladders, and one was diagnosed as carcinoma-in-situ. The papilloma in one sand rat revealed transition to adenocarcinoma, with penetration into the deep layers of the gallbladder. Preneoplastic nodules were found in the liver as frequently as reported previously, but they were unrelated to gallbladder lesions. The unusual high incidence of spontaneous epithelial proliferation in the gallbladder mucosa in sand rats of both sexes through several generations suggests this strain as a model in the experimental study of tumorigenesis in the gallbladder.
对256只7至41月龄的肥胖沙鼠（131只雄性和125只雌性）的胆囊进行了组织学研究。这些沙鼠在死亡前均未用于实验程序。在49只沙鼠中发现了胆囊黏膜的弥漫性息肉样增生或乳头状瘤。在这些病变中，45个出现在126只处于寿命后半期的沙鼠中。未发现结石或慢性炎症迹象。在两种病变形式中均可见局灶性上皮生长活性迹象。两个胆囊中的上皮增生过度，其中一个被诊断为原位癌。一只沙鼠中的乳头状瘤显示向腺癌转变，并侵入胆囊深层。在肝脏中发现的癌前结节与之前报道的频率相同，但它们与胆囊病变无关。几代以来，两性沙鼠胆囊黏膜中自发上皮增殖的异常高发生率表明该品系可作为胆囊肿瘤发生实验研究的模型。
