Lewis D J
J Comp Pathol. 1984 Apr;94(2):263-71. doi: 10.1016/0021-9975(84)90045-8.
During the routine histological examination of 2400 aged mice from lifespan carcinogenicity studies a low prevalence of glandular metaplasia of the gall bladder and of the intra-hepatic bile ducts (all associated with cholelithiasis), cholecystitis, cholangitis, papillomatous hyperplasia, papilloma, intra-mural cysts, and focal epithelial ulceration was found. The lesions were found predominantly in female mice and were not treatment related.
在对来自寿命致癌性研究的2400只老年小鼠进行常规组织学检查时，发现胆囊和肝内胆管的腺化生（均与胆石症相关）、胆囊炎、胆管炎、乳头状增生、乳头状瘤、壁内囊肿和局灶性上皮溃疡的发生率较低。这些病变主要在雌性小鼠中发现，且与治疗无关。
